In an article published in Nature, researchers at the University of Helsinki’s Institute of Biotechnology have shown how development affects the evolution of teeth, and have devised a simple developmental model to predict aspects of teeth across many species.

Researchers Kathryn Kavanagh, Jukka Jernvall, and Alistair Evans first studied molar development in mice. Similarly to human teeth, mouse molars develop from front-to-back so that the first molar appears first and the posterior molars bud sequentially along the jaw.

Normally, the last molar to develop is the third, or wisdom tooth. Experiments on cultured mouse molars revealed that the size and number of posterior molars depend on previously initiated molars. The mechanism, called an "inhibitory cascade," acts much like a ratchet that cumulatively increases size differences of teeth along the jaw. The researchers constructed a simple mathematical model that they then used to predict relative size and number of molars across many other mouse and rat species.

They showed that the model accurately predicts tooth proportions and numbers, one curious effect being that the second molar makes up one third of total molar area, irrespective of species-specific molar proportions.

This new research demonstrates that with advances in the study of the molecular regulation of development, it is now possible to identify how development influences evolution. And this may help explain the troublesome wisdom teeth of modern humans: the blame may lie within a weak inhibitory cascade that allows the development of the last molar in a jaw that is too small.

The article, "Predicting Evolutionary Patterns of Mammalian Teeth From Development," was published on September 27.